Novel Mechanism of Immune Activation in HIV-Exposed, Seronegative People Who Inject Drugs


S100A14 is a protein that mediates activation of natural killer cells, which play an essential role in fighting off the early stages of viral infections. As a recent study conducted by a team of researchers -- a team that included PISC Senior Scholar David S. Metzger -- found, S100A14 is expressed at higher levels in uninfected people who regularly partake in high-risk, needle sharing behavior in areas with high HIV prevalence. Further research into why and how this natural resistance is developed could help in battling Philadelphia's drug epidemic, and the devastating health consequences that come with drug use.

Go to Article

Back to News