Funded by the Robert Wood Johnson Health and Societies Program and the Centers for Disease Control (grant no. R49CE002474) Vacant and abandoned buildings have seen limited study in terms of their downstream health and safety effects. This series of studies involve and emerging randomized controlled trial as well as quasi-experimental methods to evaluate the health an safety impact and cost-effectiveness of remediating thousands of abandoned buildings in Philadelphia. Buildings that have been remediated are in a treatment group and buildings that have not will serve as controls. Understanding whether (and then how) the remediation of abandoned, dilapidated buildings might enhance health and safety will be important to future urban development efforts.