A team including Austin Kilaru, Jeanmarie Perrone, Kit Delgado, and Maggie Lowenstein conducted a case series investigation of patients who developed complications after starting buprenorphine in the ED for opioid use disorder, which is a rare (but feared) occurrence. Patient cases were examined to see if they met criteria for “buprenorphine-precipitated opioid withdrawal” and follow their clinical course and symptom management.